Basic Information
| LncRNA/CircRNA Name | lncRNA-TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 |
| Ensemble | ENSG00000237298 |
| Refseq | NR_038272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi, RIP |
| Sample | ESCC tissue, ESCC cell lines (Eca-109, KYSE 30, KYSE 150, KYSE180, KYSE410, KYSE450, KYSE510, TE-10 and TE-13) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-TTN-AS1 as an oncogene is highly expressed in ESCC tissues and cell lines, and promotes ESCC cell proliferation and metastasis. Mechanistically, lncRNA-TTN-AS1 promotes expression of transcription factor Snail1 by competitively binding miR-133b, resulting in the epithelial-mesenchymal transition (EMT) cascade.Moreover,lncRNA-TTN-AS1 also induces FSCN1 expression by sponging miR-133b and upregulation of mRNA-stabilizing protein HuR,which further promotes ESCC invasion cascades. |
| Pubmed ID | 29101304 |
| Year | 2017 |
| Title | Functional Role of a Novel Long Noncoding RNA TTN-AS1 in Esophageal Squamous Cell Carcinoma Progression and Metastasis. |
External Links
| Links for lncRNA-TTN-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |