Basic Information
| LncRNA/CircRNA Name | lncRNA-NEF |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-qPCR, Western blotting etc. |
| Sample | plasma,human SCLC cell lines(SHP-77 and NCI-H69) |
| Expression Pattern | down-regulated |
| Function Description | The expression level of lncRNA-NEF was lower in patients with SCLC compared with that in healthy controls. The expression level of lncRNA-NEF in the plasma was associated with distant tumor metastasis. lncRNA-NEF overexpression inhibited SCLC cell migration and invasion, resulting in TGF-?1 downregulation, while treatment with exogenous TGF-?1 reduced the inhibitory effects of lncRNA-NEF overexpression on migration and invasion. |
| Pubmed ID | 31186707 |
| Year | 2019 |
| Title | Long non-coding RNA-neighboring enhancer of FOXA2 inhibits the migration and invasion of small cell lung carcinoma cells by downregulating transforming growth factor-?1 |
External Links
| Links for lncRNA-NEF | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |