Basic Information
| LncRNA/CircRNA Name | lncRNA-NEF |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR etc. |
| Sample | plasma, osteosarcoma cell lines(MG-63 and U2OS) |
| Expression Pattern | down-regulated |
| Function Description | Downregulation of lncRNA-NEF and upregulation of miRNA-21 distinguished patients with osteosarcoma from healthy controls. lncRNA-NEF overexpression mediated the inhibition of miRNA-21 expression in osteosarcoma cell lines, while miRNA-21 overexpression did not significantly affect the expression of lncRNA-NEF. lncRNA-NEF overexpression inhibited, while miRNA-21 overexpression promoted, migration and invasion of osteosarcoma cell lines in vitro. miRNA-21 overexpression partially compensated the inhibitory effects of lncRNA-NEF overexpression on osteosarcoma cell migration and invasion. Therefore, lncRNA-NEF may inhibit cancer cell migration and invasion in osteosarcoma by downregulating miRNA-21. |
| Pubmed ID | 31186758 |
| Year | 2019 |
| Title | lncRNA-NEF Is Downregulated in Osteosarcoma and Inhibits Cancer Cell Migration and Invasion by Downregulating miRNA-21 |
External Links
| Links for lncRNA-NEF | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |