Basic Information
| LncRNA/CircRNA Name | lncRNA-NEF |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | intrahepatic cholangiocarcinoma |
| ICD-0-3 | C22 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | tumor tissue and adjacent healthy tissues ,blood was extracted from both IHCC patients and healthy controls ,human IHCC cell lines(HuCCT1 and TFK-1) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA-NEF was down-regulated, while Runt-related transcription factor 1 (RUNX1) was up-regulated in tumor tissues than in adjacent healthy tissues of IHCC patients.Plasma levels of lncRNA-NEF were significantly lower in IHCC patients than in healthy controls.Patients with high plasma levels of lncRNA-NEF showed significantly better survival conditions compared with patients with low expression levels of lncRNA-NEF.LncRNA-NEF overexpression led to inhibited expression of RUNX1 in cells of IHCC cell lines and inhibited cancer cell migration and invasion. |
| Pubmed ID | 31015363 |
| Year | 2019 |
| Title | Down-regulation of lncRNA-NEF Indicates Poor Prognosis in Intrahepatic Cholangiocarcinoma |
External Links
| Links for lncRNA-NEF | GenBank HGNC NONCODE |
| Links for intrahepatic cholangiocarcinoma | OMIM COSMIC |