Basic Information
| LncRNA/CircRNA Name | lncRNA-MIF |
| Synonyms | GIF, GLIF |
| Region | GRCh38_22:23894004-23895227 |
| Ensemble | ENSG00000240972 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | cell line (MCF7) |
| Expression Pattern | differential expression |
| Function Description | In this study, we demonstrate that lncRNA??IF (Myc inhibitory factor), which is transcribed by c??yc, is able to reduce c??yc expression. Mechanistically, lncRNA??IF competes with coding mRNA Fbxw7 for miR??86 and relieves the inhibitory effect of miR??86 on Fbxw7, thereby leading to increased Fbxw11 expression and decreased c-Myc level. |
| Pubmed ID | 27317567 |
| Year | 2016 |
| Title | LncRNA-MIF, a c-Myc-activated long non-coding RNA, suppresses glycolysis by promoting Fbxw11-mediated c-Myc degradation |
External Links
| Links for lncRNA-MIF | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |