Basic Information
| LncRNA/CircRNA Name | lncRNA-LET |
| Synonyms | NPTN-IT1, lncRNA-LET |
| Region | GRCh38_15:73567012-73569294 |
| Ensemble | ENSG00000281183 |
| Refseq | NR_103844 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RIP, in vitro knockdown etc. |
| Sample | CRC tissues, cell lines (QSG-7701, LO2, SMMC-7721 etc.) |
| Expression Pattern | down-regulated |
| Function Description | Aberrant Expression of lncRNA-LET in Tumor Tissue. We found that the lncRNA-LET was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. hypoxia-induced histone deacetylase 3 repressed lncRNA-LET by reducing the histone acetylation-mediated modulation of the lncRNA-LET promoter region. The downregulation of lncRNA-LET was found to be a key step in the stabilization of nuclear factor 90 protein, which leads to hypoxia-induced cancer cell invasion. |
| Pubmed ID | 23395002 |
| Year | 2013 |
| Title | Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. |
External Links
| Links for lncRNA-LET | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |