Basic Information
| LncRNA/CircRNA Name | lncRNA-LET |
| Synonyms | NPTN-IT1, lncRNA-LET |
| Region | GRCh38_15:73567012-73569294 |
| Ensemble | ENSG00000281183 |
| Refseq | NR_103844 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | LAC tissues, cell lines (16HBE, PC-9, H358, SPCA1, H1975, H1299, A549) |
| Expression Pattern | down-regulated |
| Function Description | RT-PCR results indicated that frequent downregulation of lncRNA-LET in LAC tissues was related to clinicopathologic factors. lncRNA-LET knockdown significantly promoted LAC cell proliferation, invasion, and migration while lncRNA-LET overexpression obviously inhibited LAC cell proliferation, invasion, and migration, indicating a tumor inhibition of lncRNA-LET in LAC progression. Besides, lncRNA-LET inhibited EMT and negatively regulated Wnt/B-catenin pathway in part. |
| Pubmed ID | 27896272 |
| Year | 2016 |
| Title | Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma. |
External Links
| Links for lncRNA-LET | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |