Basic Information
| LncRNA/CircRNA Name | lncRNA-LET |
| Synonyms | NPTN-IT1, lncRNA-LET |
| Region | GRCh38_15:73567012-73569294 |
| Ensemble | ENSG00000281183 |
| Refseq | NR_103844 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | RT-PCR , Western blot , RIP etc. |
| Sample | ESCC cell lines(KYSE30 and Eca-109) |
| Expression Pattern | NA |
| Function Description | The NF90/miR-548k/lncRNA-LET feedback loop controls the expression of HIF-1?, VEGF, KLF10, EGFR, and p53.Activation of the NF90/miR-548k/lncRNA-LET feedback loop significantly promotes ESCC cell proliferation and migration in vitro and ESCC xenograft growth in vivo.Targeting the NF90/miR-548k/lncRNA-LET feedback loop significantly represses ESCC cell proliferation and migration in vitro and ESCC xenograft growth in vivo |
| Pubmed ID | 31602267 |
| Year | 2019 |
| Title | An NF90/long Noncoding RNA-LET/miR-548k Feedback Amplification Loop Controls Esophageal Squamous Cell Carcinoma Progression |
External Links
| Links for lncRNA-LET | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |