Basic Information
| LncRNA/CircRNA Name | lncRNA-HIT |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP, ChIP, RNA pull-down assay etc. |
| Sample | cell lines (SK-MES-1, NCI-H1650, A549, NCI-H1975, 95D) |
| Expression Pattern | up-regulated |
| Function Description | The expression of lncRNA-HIT was significantly upregulated in NSCLC tissues and cell lines, and the expression level of lncRNA-HIT correlates with advanced disease stage and predicts unfavorable prognosis of NSCLC patients. Functional assays demonstrated that lncRNA-HIT markedly increased the ability of NSCLC cells to migrate and invade. |
| Pubmed ID | 27790864 |
| Year | 2016 |
| Title | Upregulation of LncRNA-HIT promotes migration and invasion of non-small cell lung cancer cells by association with ZEB1. |
External Links
| Links for lncRNA-HIT | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |