Basic Information
| LncRNA/CircRNA Name | HIF2PUT |
| Synonyms | EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 |
| Region | GRCh38_2:46293667-46386703 |
| Ensemble | ENSG00000116016 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | CRC tissues, cell lines (SW620, SW480, HT29, HCT116, CACO2, DLD-1, LS174T, and RKO) |
| Expression Pattern | up-regulated |
| Function Description | Herein, we showed that expression of both lncRNA-HIF2PUT and HIF-2a were significantly higher in CRC cell lines than in a normal colon epithelial cell line FHC. We showed that the expression of lncRNA-HIF2PUT was significantly correlated with HIF-2a in colorectal cancer (CRC) tissues. Knockdown of lncRNA-HIF2PUT blocked the HIF-2a expression and inhibited the CSC properties in CRC cell lines DLD-1 and HT29. LncRNA-HIF2PUTsmall interfering RNA transfection resulted in decreased stemness genes expression, impaired colony formation, and spheroid formation ability, retarded migration, and invasion of the cells |
| Pubmed ID | 26648739 |
| Year | 2015 |
| Title | Knockdown of a HIF-2a promoter upstream long noncoding RNA impairs colorectal cancer stem cell properties in vitro through HIF-2a downregulation. |
External Links
| Links for HIF2PUT | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |