Basic Information
| LncRNA/CircRNA Name | lncRNA-GAS1RR |
| Synonyms | NA |
| Region | GRCh38_9:86948699-87002033 |
| Ensemble | ENSG00000226237 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (MCF-7, Hs578T, BT549, MDA-MB-231, MCF10A) |
| Expression Pattern | up-regulated |
| Function Description | The Shh-GLI1 pathway associated lncRNA-Hh, transcriptionally regulated by Twist, directly targets GAS1 to stimulate the activation of hedgehog signaling (Hh). The activated Hh increases GLI1 expression, and enhances the expression of SOX2 and OCT4 to play a regulatory role in CSC maintenance. Thus, the mammosphere-formation efficiency (MFE) and the self-renewal capacity in vitro, and oncogenicity in vivo in Twist-positive breast cancer cells are elevated. lncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor. |
| Pubmed ID | 26418365 |
| Year | 2016 |
| Title | LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway. |
External Links
| Links for lncRNA-GAS1RR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |