Basic Information
| LncRNA/CircRNA Name | lncRNA-HEIH |
| Synonyms | HEIH, HCCAT2, LINC-HEIH, LINC00848, lncRNA-HEIH |
| Region | GRCh38_5:180829954-180831605 |
| Ensemble | ENSG00000278970 |
| Refseq | NR_045680 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | cell lines (MHCC97L, HepG2, cHL-7702) |
| Expression Pattern | up-regulated |
| Function Description | The expression of HEIH and HULC in hepatocellular carcinoma cell line was significantly increased compared with human normal hepatocyte line. The expression of HULC in HepG2 was higher than that in MHCC97L. The over-expression of HULC could enhance proliferation of MHCC97L and HepG2, however, the over-expression of HEIH could not. The over-expression of HULC and HEIH could promote invasion of MHCC97L and HepG2. Invasion of MHCC97L and HepG2 did not have significant change after down-regulating of HEIH and HULC by siRNA. Over-expression of HULC up-regulated the expression of Snail in HepG2. |
| Pubmed ID | 26550214 |
| Year | 2015 |
| Title | Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells. |
External Links
| Links for lncRNA-HEIH | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |