Basic Information
| LncRNA/CircRNA Name | lncRNA-HEIH |
| Synonyms | HEIH, HCCAT2, LINC-HEIH, LINC00848, lncRNA-HEIH |
| Region | GRCh38_5:180829954-180831605 |
| Ensemble | ENSG00000278970 |
| Refseq | NR_045680 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot etc. |
| Sample | cell line (NCM460, CRC, HT-29, SW480, HCT116) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we found that lncRNA-HEIH is significantly increased in CRC tissues and cell lines. lncRNA-HEIH expression is positively associated with tumor size, invasion depth, and poor prognosis of CRC patients. Enhanced expression of lncRNA-HEIH promotes CRC cell proliferation and decreases apoptosis in vitro, and promotes CRC tumor growth in vivo. Whereas knockdown of lncRNA-HEIH inhibits CRC cell proliferation and induces apoptosis in vitro, and suppresses CRC tumor growth in vivo. Mechanistically, lncRNA-HEIH physically binds to miR-939. The interaction between lncRNA-HEIH and miR-939 damages the binding between miR-939 and nuclear factor kB (NF-kB), increases the binding of NF-kB to Bcl-xL promoter, and promotes the transcription and expression of Bcl-xL. |
| Pubmed ID | 29081216 |
| Year | 2017 |
| Title | Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939-Mediated Transcriptional Repression of Bcl-xL |
External Links
| Links for lncRNA-HEIH | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |