Basic Information
| LncRNA/CircRNA Name | lncRNA-ELF209 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | HCC and their matched peritumoral tissues ,HCC cell lines with high-metastatic potentials(MHCC97H and HCCLM3),HCC cell lines with low-metastatic potentials( PLC/PRF/5, HepG2 and Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | HNRNPAB represses lnc-ELF209 transcription by directly binding to its promoter region.There is a negative relationship between HNRNPAB and lnc-ELF209 expression.lnc-ELF209 inhibits cell migration, invasion and epithelial-mesenchymal transition regulated by HNRNPAB.Furthermore,lnc-ELF209 could stabilize TPI protein expression.lnc-ELF209 overexpression in HCCLM3 cell resulted in a lower rate of lung metastatic, which suggested a less aggressive HCC phenotype. |
| Pubmed ID | 31090062 |
| Year | 2019 |
| Title | HNRNPAB-regulated lncRNA-ELF209 Inhibits the Malignancy of Hepatocellular Carcinoma |
External Links
| Links for lncRNA-ELF209 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |