Basic Information
| LncRNA/CircRNA Name | lncRNA-CLMAT3 |
| Synonyms | CTB-113P19.1, CLMAT3 |
| Region | GRCh38_5:151676945-151724782 |
| Ensemble | ENSG00000249035 |
| Refseq | NR_109873 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Immunoprecipitation etc. |
| Sample | cell lines (HT-29, SW480, SW620, HCT116, LOVO, and CCC-HIE-2) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we demonstrate that lncRNA-CLMAT3 expression was significantly increased in colorectal cancer cells compared with a normal intestinal mucous cell line and that inhibition of lncRNA-CLMAT3 suppressed colorectal cancer cell proliferation in vitro. We also found that this reduced colorectal cancer cell proliferation due to lncRNA-CLMAT3 knockdown is associated with G0/G1 cell-cycle arrest induction and apoptosis enhancement. Furthermore, lncRNA-CLMAT3 knockdown enhanced Cdh1 expression and resulted in p27Kip accumulation via increased Skp2 protein ubiquitination. |
| Pubmed ID | 27391344 |
| Year | 2016 |
| Title | Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway. |
External Links
| Links for lncRNA-CLMAT3 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |