Basic Information
| LncRNA/CircRNA Name | lncRNA-CIR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, in vitro knockdown |
| Sample | 52 cancerous tissues and bladder cancer cell lines(T24, SW780, UBC-40, 5637 and UM-UC-3 ) |
| Expression Pattern | up-regulated |
| Function Description | upregulating lncRNA-CIR was demonstrated to promote viability and invasion in T24 and SW780 cells, whereas siRNA-mediated lncRNA-CIR-knockdown consistently exhibited the opposite effects. High lncRNA-CIR levels also dictated poor overall survival among patients with bladder cancer. Furthermore, in vivo implantation experiments also supported a tumorigenic function for lncRNA-CIR, as decreasing lncRNA-CIR levels markedly attenuated Ki-67 staining and xenograft tumor growt |
| Pubmed ID | 29435036 |
| Year | 2017 |
| Title | Long non-coding RNA cartilage injury-related promotes malignancy in bladder cancer. |
External Links
| Links for lncRNA-CIR | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |