Basic Information
LncRNA/CircRNA Name | lncRNA-cCSC1 |
Synonyms | gene symbol MAPKAPK5-AS1 |
Region | NA |
Ensemble | NA |
Refseq | NA |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | qRT-PCR, Western blot assay |
Sample | CRC and adjacent normal tissues,colon mucosal epithelial cell line NCM460 and human CRC cell lines Caco2, SW480, SW620, LoVo, HT29, and HCT116 |
Expression Pattern | up-regulated |
Function Description | The biological functions of lncRNA-cCSC1 were assessed in vitro and vivo through the silencing or upregulation of its expression. The depletion of lncRNA-cCSC1 markedly inhibited the self-renewal capacity of the CRCSCs and reduced their drug resistance to 5-fluorouracil. In contrast, lncRNA-cCSC1 overexpression increased the self-renewal effect. Furthermore, aberrant lncRNA-cCSC1 expression resulted in a concomitant alteration of smoothened (SMO) and GLI family zinc finger 1 (Gli1) expression in the Hedgehog (Hh) signaling pathway. |
Pubmed ID | 31680315 |
Year | 2020 |
Title | LncRNA-cCSC1 Modulates Cancer Stem Cell Properties in Colorectal Cancer via Activation of the Hedgehog Signaling Pathway |
External Links
Links for lncRNA-cCSC1 | GenBank HGNC NONCODE |
Links for colorectal cancer | OMIM COSMIC |