Basic Information
| LncRNA/CircRNA Name | lncRNA-BGL3 |
| Synonyms | BGLT3, BGL3, LINC01083, lncRNA-BGL3 |
| Region | GRCh38_11:5244554-5245546 |
| Ensemble | ENSG00000260629 |
| Refseq | NR_121648 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic myeloid leukemia |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | cell line (K562) |
| Expression Pattern | up-regulated |
| Function Description | We observed that lncRNA-BGL3 was highly induced in response to disruption of Bcr-Abl expression or by inhibiting Bcr-Abl kinase activity in K562 cells and leukemic cells derived from CML patients. Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhibited Bcr-Abl-induced tumorigenesis. |
| Pubmed ID | 24837367 |
| Year | 2015 |
| Title | A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA. |
External Links
| Links for lncRNA-BGL3 | GenBank HGNC NONCODE |
| Links for chronic myeloid leukemia | OMIM COSMIC |