Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | malignant melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Flow cytometry assay, Luciferase reporter assay, etc. |
| Sample | MM cell lines, normal human epidermal melanocyte cell lines. MM tissues. |
| Expression Pattern | up-regulated |
| Function Description | In conclusion, the present study revealed the expression and roles of lncRNA?ATB in MM, and indicated that lncRNA?ATB functions as a ceRNA to promote MM proliferation and invasion by sponging miR?590?5p. Despite the notable improvements in diagnosis and treatment made in recent years, the prognosis remains poor for patients diagnosed at the metastatic stage, with a median survival time of 6-9 months and a 5-year survival rate of only 10% (2-4). Finally, it was demonstrated that lncRNA?ATB functions as a competing endogenous RNA (ceRNA) to enhance Yes associated protein 1 expression by competitively sponging microRNA miR?590?5p in MM cells. |
| Pubmed ID | 29956757 |
| Year | 2018 |
| Title | lncRNA-ATB functions as a competing endogenous RNA to promote YAP1 by sponging miR-590-5p in malignant melanoma. |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for malignant melanoma | OMIM COSMIC |