Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR etc. |
| Sample | HCC tissues, cell lines (SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we observed that the lncRNA-activated by TGFB1 (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion. In addition, lncRNA-ATB promoted organ colonization of disseminated tumor cells by binding IL-11 mRNA, autocrine induction of IL-11, and triggering STAT3 signaling. |
| Pubmed ID | 24768205 |
| Year | 2014 |
| Title | A long noncoding RNA activated by TGFB1-promotes the invasion-metastasis cascade in hepatocellular carcinoma. |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |