Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Cell transfection, Western blot, Luciferase reporter assay, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | gastric cancer tissues, cell lines (BGC823 and SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | lnc-ATB was significantly upregulated in GC tissues compared to lnc-ATB expression in ANTs.These high lnc-ATB expression levels predicted poor prognosis in GC patients. Low levels of lnc-ATB inhibited GC cell proliferation and cell cycle arrest in vitro. Lnc-ATB was found to directly bind miR-141-3p. Moreover, TGF-B actives lnc-ATB and TGF-B2 directly binds mir-141-3p.Finally, we demonstrated that lnc-ATB fulfilled its oncogenic roles in a ceRNA-mediated manner. |
| Pubmed ID | 28115163 |
| Year | 2017 |
| Title | Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFB2 feedback loop. |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |