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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	renal cell carcinoma
ICD-0-3	C64.9
Methods	qPCR, RNAi, Western blot, Cell proliferation assay etc.
Sample	RCC tissues, cell lines (786-O, A498, ACHN)
Expression Pattern	up-regulated
Function Description	The expression of lncRNA-ATB was higher in the renal cell carcinoma tissues and renal cancer cells than in the adjacent non-tumor tissues and normal human proximal tubule epithelial cells HK-2. In addition, the lncRNA-ATB expression was significantly higher in the renal cell carcinoma patients with metastasis. The elevated expression of lncRNA-ATB was associated with tumor stages, histological grade, vascular invasion, lymph node metastasis and distant metastasis. Notably, we found that lncRNA-ATB knockdown could (i) inhibit cell proliferation; (ii) trigger apoptosis; (iii) reduce epithelial-to-mesenchymal transition program; (iv) suppress cell migration and invasion.
Pubmed ID	26848077
Year	2016
Title	High expression of long non-coding RNA lncRNA-ATB is correlated with metastases and promotes cell migration and invasion in renal cell carcinoma.

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