Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR etc. |
| Sample | PTC tissues, cell lines (IHH-4, TPC-1, K1, HTH83, Nthy-ori 3-1) |
| Expression Pattern | up-regulated |
| Function Description | ATB is upregulated in PTC tissues compared with noncancerous tissues. ATB is upregulated and functions as an oncogene in PTC. Furthermore, lncRNA-ATB may serve as a diagnostic biomarker and therapeutic target for PTC. High-expression of lncRNA-ATB is associated with large tumor size and lymph node metastasis. LncRNA-ATB has been reported to promote cancer metastasis via binding and negatively regulating miR-200 family,and then inducing epithelial-mesenchymal transition22. |
| Pubmed ID | 28770959 |
| Year | 2017 |
| Title | The expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer. |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |