Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot etc. |
| Sample | colon tumor tissues,cell lines (HCT116 and HT29) |
| Expression Pattern | differential expressed |
| Function Description | Knockdown of ATB impaired colony formation and sphere formation in CRC cells, accompanied by an inhibition of colon tumor growth. Further results suggested that ATB regulated the transcriptional activity of the ?-catenin pathway by inhibiting ?-catenin expression. In addition, the results confirmed the role of ?-catenin in ATB-mediated regulation of stemness in CRC. Collectively, the results indicated that ATB is a promising therapeutic target for CRC. |
| Pubmed ID | 32256798 |
| Year | 2020 |
| Title | lncRNA-ATB promotes stemness maintenance in colorectal cancer by regulating transcriptional activity of the ?-catenin pathway |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |