Basic Information
LncRNA/CircRNA Name | lncRNA-AP001631.9 |
Synonyms | FRGCA |
Region | GRCh38_21:43140523-43141092 |
Ensemble | ENSG00000236663 |
Refseq | NR_133677 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | gastric cancer |
ICD-0-3 | C16 |
Methods | qPCR, RNAi etc. |
Sample | gastric cancer tissues, cell lines (AGS, MGC803, BGC823 and SGC7901) |
Expression Pattern | up-regulated |
Function Description | The downregulation of LncRNA-AP001631.9 by small interference RNA suppressed the migratory ability of MGC803 and AGS cells, while the overexpression of LncRNA-AP001631.9 promoted the movement of BGC823 and SGC7901 cells. Furthermore, a tail vein injection was administered, and the obtained results suggested that LncRNA-AP001631.9 contributed to the distant metastasis of SGC7901 cells. Our findings established that LncRNA-AP001631.9 plays critical roles in gastric cancer progression and can serve as a potential new target for the treatment of gastric cancer. |
Pubmed ID | 26261500 |
Year | 2015 |
Title | LncRNA-AP001631.9 promotes cell migration in gastric cancer |
External Links
Links for lncRNA-AP001631.9 | GenBank HGNC NONCODE |
Links for gastric cancer | OMIM COSMIC |