Basic Information
| LncRNA/CircRNA Name | lncRNA-AK058803 |
| Synonyms | NA |
| Region | GRCh38_10:86948677-86949657 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, RNAi, in vitro knockdown etc. |
| Sample | gastric cancer tissues, cell lines (SGC7901, MKN45, MKN28) |
| Expression Pattern | up-regulated |
| Function Description | AK058003 is frequently upregulated in GC samples and promotes GC migration and invasion in vivo and in vitro. Next, we identified ?-synuclein. (SNCG), which is a metastasis-related gene regulated by AK058003. In addition, we found that the expression of SNCG is positively correlated with that of AK058003 in the clinical GC samples used in our study. Furthermore, we found that the SNCG gene CpG island methylation was significantly increased in GC cells depleted of AK058003. Intriguingly, SNCG expression is also increased by hypoxia, and SNCG upregulation by AK058003 mediates hypoxia-induced GC cell metastasis. |
| Pubmed ID | 25499222 |
| Year | 2014 |
| Title | Hypoxia-Inducible lncRNA-AK058003 Promotes Gastric Cancer Metastasis by Targeting ?-synuclein. |
External Links
| Links for lncRNA-AK058803 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |