Basic Information
LncRNA/CircRNA Name | lncRNA-AK058803 |
Synonyms | NA |
Region | GRCh38_10:86948677-86949657 |
Ensemble | NA |
Refseq | NA |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | hepatocellular carcinoma |
ICD-0-3 | C22.0 |
Methods | qPCR, RNAi, Western blot, Flow cytometry assay, RNA pull-down assay, Cell proliferation assay etc. |
Sample | HCC tissues, cell lines (HepG2, SK-Hep1, HEK 293T) |
Expression Pattern | down-regulated |
Function Description | We found that lncRNA-AK058003 is down-regulated in hepatocellular carcinoma tissues and it is associated with the relapse and metastasis of the cancer. Furthermore, lncRNA-AK058003 acts as a tumor suppressor, suppressing hepatocellular carcinoma cell proliferation and metastasis in vitro and in vivo. lncRNA-AK058003 can reduce mRNA stabilizing protein HuR, which results in the inhibition of the expression of ?-synuclein. |
Pubmed ID | 28035067 |
Year | 2017 |
Title | Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of ?-synuclein in hepatocellular carcinoma cells. |
External Links
Links for lncRNA-AK058803 | GenBank HGNC NONCODE |
Links for hepatocellular carcinoma | OMIM COSMIC |