Basic Information
| LncRNA/CircRNA Name | lncRNA-422 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR |
| Sample | cell lines (NCM460, SW480, HCT116, DLD-1, HT29, and SW620) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA-422(ENST00000415820) significantly downregulated in the tissues and serum of CRC patients, and is closely associated with the poor prognosis. lncRNA-422 overexpression inhibited cell proliferation, migration, and invasion. Knockdown of lncRNA-422 promoted tumorigensis.lncRNA-422 acts as a tumor suppressor by PI3K/AKT/mTOR pathway in CRC.CRC patients with high expression of lncRNA-422 had a significantly longer survival time than those with low lncRNA-422 expression. |
| Pubmed ID | 29050940 |
| Year | 2017 |
| Title | Long non-coding RNA-422 acts as a tumor suppressor in colorectal cancer |
External Links
| Links for lncRNA-422 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |