Basic Information
| LncRNA/CircRNA Name | lncRNA-135528 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Microarra, RNAi, other |
| Sample | malignant glioblastoma multiforme tissues and cell line (U87MG) |
| Expression Pattern | up-regulated |
| Function Description | The main findings indicated that lncRNA-135528 promoted glioma cell apoptosis, inhibited cell proliferation and arrested cell cycle progression; the up-regulation of lncRNA135528 led to significantly increased CXCL10 levels and the differential expression of mRNA associated with JAK/STAT pathway in glioma cells. lncRNA-135528 can inhibit tumor progression by up-regulating CXCL10 through the JAK/STAT pathway. |
| Pubmed ID | 30232656 |
| Year | 2018 |
| Title | LncRNA-135528 Inhibits Tumor Progression by Up-Regulating CXCL10 Through the JAK/STAT Pathway |
External Links
| Links for lncRNA-135528 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |