Basic Information
| LncRNA/CircRNA Name | lnc-RBMY2FP |
| Synonyms | RBMY2FP |
| Region | GRCh38_Y:22308859-22321825 |
| Ensemble | ENSG00000243040 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP, ChIP, Cell cycle assay etc. |
| Sample | HCC tissues, cell lines (SMMC-7721 and HepG2) |
| Expression Pattern | up-regulated |
| Function Description | We found that lnc-RBMY2FP was specifically expressed in 5 male patients' tumor tissues, while lnc-RBMY2FP was not detectable in compared adjacent non-tumor tissues, nor in the other 10 male patients or female patients. Lnc-RBMY2FP enhances HCC cell growth, proliferation and tumor stemness both in vitro and in vivo. Mechanistically, lnc-RBMY2FP interacts with DNMT1 and hampers its binding onto promoters of RBMY gene family. Thus, maintenance of promoter methylation status is disturbed because of inhibition of DNMT1 activity, leading to increased expression of RBMY1A1 protein and enhanced hepatocarcinogenesis. |
| Pubmed ID | 27487148 |
| Year | 2016 |
| Title | Long non-coding RNA RBMY2FP promotes proliferation of male hepatocellular carcinoma by directing DNA methylation and activating RBMY1A1 via DNMT1. |
External Links
| Links for lnc-RBMY2FP | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |