Basic Information
| LncRNA/CircRNA Name | lncPARP1 |
| Synonyms | lncPARP1 |
| Region | GRCh38_1: 226083639-226090292 |
| Ensemble | ENSG00000225518 |
| Refseq | NR_146920 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, western blot etc. |
| Sample | hepatocellular carcinoma tissue, cell lines (SMMC-7721, HepG2, Huh7, SK-Hep-1, PLC/PRF/5, and Bel-7402) |
| Expression Pattern | up-regulated |
| Function Description | Here, we identified a novel oncogenic lncRNA termed as lncPARP1, which was significantly up-regulated in HCC. Increase in lncPARP1 expression was associated with age, a-fetoprotein (AFP) levels, tumor size, recurrence, and poor prognosis of HCC patients. |
| Pubmed ID | 29776974 |
| Year | 2018 |
| Title | The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1 |
External Links
| Links for lncPARP1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |