Basic Information
| LncRNA/CircRNA Name | lnc-OC1 |
| Synonyms | FRP,FSL1,OCC1,OCC-1,tsc36,MIR198 |
| Region | GRCh38_3:120392293-120451253 |
| Ensemble | ENSG00000163430 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, luciferase report assay, Western blot, in vitro knockdown |
| Sample | cell line (HEY-T30, SKOV4), bladder cancer |
| Expression Pattern | up-regulated |
| Function Description | Lnc-OC1 expression was associated with poor prognosis of OC patients.knockdown of Lnc-OC1 suppressed cell proliferation, colony formation, invasion and migration in vitro and inhibited tumorigenicity in vivo.lnc-OC1 repressed the expression of endogenous miR-34a and miR-34c as a sponge andvice versa. Moreover, rescue experiments demonstrated that the oncogenic function of Lnc-OC1 at leastpartially depended on suppressing miR-34a and miR-34c. |
| Pubmed ID | 29576507 |
| Year | 2018 |
| Title | A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-35c. |
External Links
| Links for lnc-OC1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |