Basic Information
| LncRNA/CircRNA Name | lncMX1-215 |
| Synonyms | ENST00000486275 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western blotting, RIP, In vivo analysis |
| Sample | HNSCC tissues,HNSCC cell lines HN4, HN6 and HN30,Cal27, SCC4, SCC25, Detroit 562 and 293?? cells |
| Expression Pattern | down-regulated |
| Function Description | IFN?-induced lncRNA, lncMX1-215, whose expression was dependent on Stat1 phosphorylation. LncMX1-215 upregulation markedly inhibited PD-L1 and galectin-9 expression by interrupting GCN5-mediated H3K27 acetylation. The IFN?-lncMX1-215-GCN5-H3K27ac axis creates a novel feedback loop that disrupts immunosuppression formation in the tumor microenvironment. |
| Pubmed ID | 31907020 |
| Year | 2020 |
| Title | A Novel IFN?-induced Long Noncoding RNA Negatively Regulates Immunosuppression by Interrupting H3K27 Acetylation in Head and Neck Squamous Cell Carcinoma |
External Links
| Links for lncMX1-215 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |