Basic Information
| LncRNA/CircRNA Name | lnc-MUC20-9 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | RNA-seq, qRT-PCR, RIP, Western blot analysis |
| Sample | BC cells SW780, T24, TCCSUP, UM-UC-3, 5637, and HEK293T |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of lnc-MUC20-9 in 5637 and T24 cells resulted in decreased tumor cell viability and cell clones, decreased migration and invasion, and increased apoptosis. Similarly, nude mice bearing lnc-MUC20-9 overexpressing tumor cells exhibited smaller tumor size and volume than that of mice bearing control cells. Mass spectrometry analysis showed that lnc-MUC20-9 binds to ROCK1, an oncogene whose expression was decreased in lnc-MUC20-9 overexpressing cells. |
| Pubmed ID | 31898364 |
| Year | 2020 |
| Title | Lnc-MUC20-9 Binds to ROCK1 and Functions as a Tumor Suppressor in Bladder Cancer |
External Links
| Links for lnc-MUC20-9 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |