Basic Information
| LncRNA/CircRNA Name | ARNILA |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | triple negative breast cancer tissues, cell lines (MDA-MB-231 and Hs578T) |
| Expression Pattern | up-regulated |
| Function Description | We performed experiments with or without DHT treatment in three TNBC cell lines, and we identified an AR negatively induced lncRNA (ARNILA), which correlated with poor progression-free survival (PFS) in TNBC patients and promoted epithelial-mesenchymal transition (EMT), invasion and metastasis in vitro and in vivo. Subsequently, we demonstrated that ARNILA functioned as a competing endogenous RNA (ceRNA) for miR-204 to facilitate expression of its target gene Sox4, which is known to induce EMT and contribute to breast cancer progression, thereby promoting EMT, invasion and metastasis of TNBC. |
| Pubmed ID | 29844570 |
| Year | 2018 |
| Title | An Androgen Receptor Negatively Induced Long Non-Coding RNA ARNILA Binding to miR-204 Promotes the Invasion and Metastasis of Triple-Negative Breast Cancer |
External Links
| Links for ARNILA | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |