Basic Information
| LncRNA/CircRNA Name | lncGPR107 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | hepatocellular carcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | GPR107 was the most highly expressed GPCR in liver cancer and liver TICs. The expression pattern of GPR107 was associated with liver tumor clinical characteristics, including metastasis, relapse and prognosis. GPR107 was essential for the self-renewal of liver TICs. The expression of GPR107 was regulated by a long noncoding RNA lncGPR107. LncGPR107 was also highly expressed in liver cancers and liver TICs. LncGPR107 drove the self-renewal of liver TICs through GPR107. Moreover, lncGPR107 recruited SRCAP complex to GPR107 promoter to drive its transcriptional activation. LncGPR107 depletion inhibited the binding of SRCAP complex and GPR107 promoter and subsequent GPR107 expression. Moreover, LncGPR107-SRCAP-GPR107 can be targeted for liver TIC elimination. |
| Pubmed ID | 29925408 |
| Year | 2018 |
| Title | LncGPR107 Drives the Self-Renewal of Liver Tumor Initiating Cells and Liver Tumorigenesis Through GPR107-dependent Manner |
External Links
| Links for lncGPR107 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |