Basic Information
LncRNA/CircRNA Name | lnc-DILC |
Synonyms | TFDP1, DILC, DP1, DRTF1, Dp-1 |
Region | GRCh38_13:113584721-113641470 |
Ensemble | ENSG00000198176 |
Refseq | NA |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | qPCR, Western blot, in vitro knockdown, Luciferase reporter assay etc. |
Sample | cell line (HCT116,SW480), CRC tissues |
Expression Pattern | down-regulated |
Function Description | lnc-DILC overexpression inhibited the growth and metastasis of CRC cells. Consistently, lnc-DILC knockdown facilitated the proliferation and metastasis of CRC cells. Mechanically, lnc-DILC suppressed CRC cell progression via IL-6/STAT3 signaling inactivation. More importantly, the specific STAT3 inhibitor S3I-201 and IL-6R inhibitor tocilizumab abolished the discrepancy of growth and metastasis capacity between lnc-DILC-interference CRC cells and control cells, which further confirmed that IL-6/STAT3 signaling was required in lnc-DILC-disrupted CRC cell growth and metastasis. Taken together, our results suggest that lnc-DILC is a novel CRC suppressor and may prove to be an inhibitor of CRC progression by inactivating IL-6/STAT3 signaling. |
Pubmed ID | 29621586 |
Year | 2018 |
Title | Long non-coding RNA DILC suppresses cell proliferation and metastasis in colorectal cancer. |
External Links
Links for lnc-DILC | GenBank HGNC NONCODE |
Links for colorectal cancer | OMIM COSMIC |