Basic Information
| LncRNA/CircRNA Name | lnc-DILC |
| Synonyms | TFDP1, DILC, DP1, DRTF1, Dp-1 |
| Region | GRCh38_13:113584721-113641470 |
| Ensemble | ENSG00000198176 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | ccRCC and matched normal tissues ,human ccRCC cell lines(ACHN, 786-O, 769-P,Caki-1 and OS-RC-2), and a normal human renal cell line HK-2 |
| Expression Pattern | down-regulated |
| Function Description | lnc-DILC levels were dramatically downregulated in ccRCC tissues. Loss of lnc-DILC expression was correlated with larger tumor size, advanced tumor grade and lymph node metastasis, and also predicted worse prognosis in patients with ccRCC.Functionally, lnc-DILC inhibited cell proliferation, migration and invasion in ccRCC cells. lnc-DILC bound to tumor suppressor PTEN and suppressed its degradation. lnc-DILC repressed the PTEN ubiquitination through blocking the interaction between PTEN and E3 ubiquitin ligase WWP2 and recruiting the deubiquitinase USP11 to PTEN. Moreover, we demonstrated that PTEN-AKT signaling was crucial for lnc-DILC-mediated suppressive effects. |
| Pubmed ID | 31592114 |
| Year | 2019 |
| Title | Long Noncoding RNA lnc-DILC Stabilizes PTEN and Suppresses Clear Cell Renal Cell Carcinoma Progression |
External Links
| Links for lnc-DILC | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |