Basic Information
| LncRNA/CircRNA Name | lnc-DILC |
| Synonyms | TFDP1, DILC, DP1, DRTF1, Dp-1 |
| Region | GRCh38_13:113584721-113641470 |
| Ensemble | ENSG00000198176 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | bladder cancer patients' tissues ,Bladder cell lines (T24 and J82 cells),BC cells |
| Expression Pattern | down-regulated |
| Function Description | lnc-DILC was downregulated in human bladder cancer tissues. Lnc-DILC overexpression suppressed the proliferation, metastasis and expansion of bladder cancer stem cells (CSCs). Mechanically, lnc-DILC suppressed BC cells progression via STAT3 pathway. STAT3 was acquired for lnc-DILC-disrupted BC cell growth, metastasis and self-renewal. |
| Pubmed ID | 31176734 |
| Year | 2019 |
| Title | Long Non-Coding RNA DILC Suppresses Bladder Cancer Cells Progression |
External Links
| Links for lnc-DILC | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |