Basic Information
| LncRNA/CircRNA Name | lnc-CCDST |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP, etc. |
| Sample | Fresh frozen CC tissues, HeLa, SiHa, C-33 A, HT-3, HUVECs, and HEK 293 T cells |
| Expression Pattern | down-regulated |
| Function Description | A long noncoding RNA, named lnc-CCDST, is significantly downregulated in CC tissues, and binds to pro-oncogenic DHX9. DHX9 is upregulated in CC tissue, and promotes CC cell motility and angiogenesis. The lnc-CCDST and DHX9 interaction promotes DHX9 degradation through the ubiquitin proteasome pathway. Furthermore, DHX9 bound to E3 ubiquitin ligase MDM2, and this interaction is enhanced by lnc-CCDST. Thus, lnc-CCDST promotes DHX9 degradation by serving as a scaffold to facilitate the formation of MDM2 and DHX9 complexes. Moreover, HPV oncogenes E6 and E7 abolish the expression of lnc-CCDST resulting in the increase of DHX9. |
| Pubmed ID | 30518908 |
| Year | 2018 |
| Title | A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer |
External Links
| Links for lnc-CCDST | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |