Basic Information
| LncRNA/CircRNA Name | ARHGAP5-AS1 |
| Synonyms | NA |
| Region | GRCh38_14:32074946-32076793 |
| Ensemble | ENSG00000258655 |
| Refseq | NR_027263 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, RIP etc. |
| Sample | Human gastric cancer cell lines SGC7901 and BGC823 |
| Expression Pattern | up-regulated |
| Function Description | Its abundance is affected by autophagy and SQSTM1 is responsible for transporting ARHGAP5-AS1 to autophagosomes. Inhibition of autophagy in chemoresistant cells, thus, resulted in the upregulation of ARHGAP5-AS1. In turn, it activated the transcription of ARHGAP5 in the nucleus by directly interacting with ARHGAP5 promoter. Interestingly, ARHGAP5-AS1 also stabilized ARHGAP5 mRNA in the cytoplasm by recruiting METTL3 to stimulate m6A modification of ARHGAP5 mRNA. As a result, ARHGAP5 was upregulated to promote chemoresistance and its upregulation was also associated with poor prognosis in gastric cancer. |
| Pubmed ID | 31097692 |
| Year | 2019 |
| Title | Impaired Autophagic Degradation of lncRNA ARHGAP5-AS1 Promotes Chemoresistance in Gastric Cancer |
External Links
| Links for ARHGAP5-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |