Basic Information
| LncRNA/CircRNA Name | lncARSR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, RIP, ChIP, RNA pull-down assay etc. |
| Sample | RCC tissues, cell lines (A498, 769P, Ketr-3, Caki-1, Caki-2) |
| Expression Pattern | up-regulated |
| Function Description | Here we show that long non-coding RNA lncARSR is upregulated in primary renal T-ICs and associated with a poor prognosis of clear cell RCCs (ccRCC). Knockdown of lncARSR attenuates the self-renewal, tumorigenicity and metastasis of renal T-ICs. |
| Pubmed ID | 27886176 |
| Year | 2016 |
| Title | A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells. |
External Links
| Links for lncARSR | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |