Basic Information
| LncRNA/CircRNA Name | lncARSR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, RNAi, Western blot, Northern blot, ChIP, Luciferase reporter assay, ISH etc. |
| Sample | RCC tissues, cell lines (786-O and ACHN) |
| Expression Pattern | up-regulated |
| Function Description | Compared with matched pre-therapy tumors, lncARSR was abundant in sunitinib-resistant RCC. lncARSR promoted sunitinib resistance via competitively binding miR-34/miR-449 to facilitate AXL and c-MET expression in RCC cells. Furthermore, bioactive lncARSR could be incorporated into exosomes and transmitted to sensitive cells, thus disseminating sunitinib resistance. Treatment of sunitinib-resistant RCC with locked nucleic acids targeting lncARSR or an AXL/c-MET inhibitor restored sunitinib response. |
| Pubmed ID | 27117758 |
| Year | 2016 |
| Title | Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. |
External Links
| Links for lncARSR | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |