Basic Information
| LncRNA/CircRNA Name | lncARSR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc |
| Sample | NSCLC and matched non-tumor samples,cell lines (16HBE,SPC-A1, A549, H23 and H1299) |
| Expression Pattern | up-regulated |
| Function Description | Moreover, ectopic expression of lncARSR suppressed PTEN expression and induced Akt phosphorylation in A549 cells. The expression level of PTEN was higher in NSCLC samples than in adjacent non-tumor specimens. PTEN expression was negatively correlated with lncARSR in NSCLC specimens. Furthermore, we demonstrated that overexpression of lncARSR induced NSCLC cell growth and migration via regulating the PTEN/Akt signaling pathway. These results suggest that lncARSR acts as an oncogene in NSCLC development and could serve as a new potential therapeutic target. |
| Pubmed ID | 32269718 |
| Year | 2020 |
| Title | LncARSR Promotes Non-Small-Cell Lung Cancer Progression via Regulating PTEN/Akt |
External Links
| Links for lncARSR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |