Basic Information
| LncRNA/CircRNA Name | lncAPP |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | tumors and matched adjacent normal tissues ,human PCa cell lines LNCaP ,human embryonic kidney cell line 293T |
| Expression Pattern | up-regulated |
| Function Description | lncAPP enhanced cell proliferation and promoted migration and invasion.Upregulation of lncAPP promoted cell migration and invasion via competitively binding miR218 to facilitate ZEB2/CDH2 expression.lncAPP/miR218 axis plays a critical role in PCa progression. |
| Pubmed ID | 31107971 |
| Year | 2019 |
| Title | The Previously Uncharacterized lncRNA APP Promotes Prostate Cancer Progression by Acting as a Competing Endogenous RNA |
External Links
| Links for lncAPP | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |