Basic Information
| LncRNA/CircRNA Name | ARHGAP27P1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-qPCR, Western blot, RIP |
| Sample | GC specimens,Plasma samples,GC cell lines SGC-7901, MGC-803, HGC-27, AGS and BGC-823 |
| Expression Pattern | down-regulated |
| Function Description | ARHGAP27P1 was significantly downregulated in GC tissues, plasma and cells.Low expression of ARHGAP27P1 was closely associated with advanced TNM stage, increased invasion depth and lymphatic metastasis. Low ARHGAP27P1 expression also predicted a poor prognosis in GC patients. Functionally, overexpression of ARHGAP27P1 inhibited proliferation, invasion, and migration in GC cells, while silencing of ARHGAP27P1 showed the opposite effects. Mechanistic investigations showed that ARHGAP27P1 had a key role in G0/G1 arrest. |
| Pubmed ID | 31665700 |
| Year | 2019 |
| Title | Long Noncoding RNA ARHGAP27P1 Inhibits Gastric Cancer Cell Proliferation and Cell Cycle Progression Through Epigenetically Regulating p15 and p16 |
External Links
| Links for ARHGAP27P1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |