Basic Information
| LncRNA/CircRNA Name | lnc712 |
| Synonyms | NONHSAT028712 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, RT-qPCR, Western blot |
| Sample | breast epithelial cells (MCF-10A, American Type Culture Collection), the human breast cancer cells MDA-MB-231 and MCF-7, and long-term adriamycin 9-treated MCF-7 cells |
| Expression Pattern | up-regulated |
| Function Description | lncRNA NONHSAT028712 (Lnc712), was highly expressed in breast cancer cell lines and tissues based on microarray screening. Knockdown of Lnc712 largely inhibited breast cancer cell proliferation. Mechanistically, Lnc712 bound specifically to heat-shock protein 90 (HSP90). Interaction between Lnc712 and HSP90 is required for HSP90 binding to cell division cycle 37 (Cdc37). The Lnc712/HSP90/Cdc37 complex regulated cyclin-dependent kinase 2 (CDK2) activation and then triggered breast cancer cell proliferation. |
| Pubmed ID | 31892853 |
| Year | 2020 |
| Title | A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation |
External Links
| Links for lnc712 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |