Basic Information
| LncRNA/CircRNA Name | lnc34a |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | cell lines (Colo205, SW480, HT29, SW620, LS174T, DLD1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Here we report a novel LncRNA, Lnc34a, that is enriched in colon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA miR-34a to cause its spatial imbalance. Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent of its upstream regulator, p53. Lnc34a levels affect CCSC self-renewal and colorectal cancer (CRC) growth in xenograft models. Lnc34a is upregulated in late-stage CRCs, contributing to epigenetic miR-34a silencing and CRC proliferation. |
| Pubmed ID | 27077950 |
| Year | 2016 |
| Title | A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division |
External Links
| Links for lnc34a | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |