Basic Information
| LncRNA/CircRNA Name | lnc01614 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (BGC-823, SGC-7901, AGS, MKN28, GES-1), gastric cancer tissue |
| Expression Pattern | up-regulated |
| Function Description | Compared with patients with low expression of lnc01614, patients with high expression of lnc01614 had higher tumor staging, greater lymph node metastasis and distant metastasis rates, and lower overall survival rate. In comparison with the negative control si-NC group, cell proliferation, invasion and migration abilities in lnc01614 knockdown expression group (si-lnc01614) were significantly decreased. Si-lnc01614 group exhibited increased E-cadherin expression, and significantly reduced vimentin and snail expression. |
| Pubmed ID | 29565488 |
| Year | 2018 |
| Title | Long noncoding RNA Lnc01614 promotes the occurrence and development of gastric cancer by activating EMT pathway. |
External Links
| Links for lnc01614 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |