Basic Information
| LncRNA/CircRNA Name | lnc015192 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, Western blot, luciferase reporter assay, RIP |
| Sample | cell lines, mice |
| Expression Pattern | up-regulated |
| Function Description | We found that Adam12 and lnc015192 were significantly upregulated in miR-34a knockout breast tissues.Knockdown of Adam12 and lnc015192 inhibited breast cancer cell migration, invasion, and epithelial-mesenchymal transition (EMT). Further experiments revealed that lnc015192 regulated Adam12 expression by functioning as a competing endogenous RNA (ceRNA) for miR-34a. |
| Pubmed ID | 30042416 |
| Year | 2018 |
| Title | Adam12 and lnc015192 Act as ceRNAs in Breast Cancer by Regulating miR-34a. |
External Links
| Links for lnc015192 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |